The di Luccio lab: Epigenetics at atomic details

Publications & Patent

31 - Biosynthesis of (R)-(-)-1-Octen-3-ol in Recombinant Saccharomyces cerevisiae with Lipoxygenase-1 and Hydroperoxide Lyase 

         Genes from Tricholoma matsutake.

         Lee NY, Choi DH, Kim MG, Jeong MJ, Kwon HJ, Kim DH, Kim YG, di Luccio E, Arioka M, Yoon HJ, Kim JG.

         J Microbiol Biotechnol. (2020) Feb 28;30(2):296-305. doi: 10.4014/jmb.2001.01049.

30 - High yield recombinant expression and purification of oncogenic NSD1, NSD2, and NSD3 with human influenza 

       hemagglutinin tag.

       Shen Y, Morishita M, di Luccio E.

       Protein Expr Purif. (2020) Feb;166:105506. doi: 10.1016/j.pep.2019.105506.

29 - Set7 Is a H3K37 Methyltransferase in Schizosaccharomyces pombe and Is Required for Proper Gametogenesis

      Yunpeng Shen, Damiaan E.H.F. Mevius, Rocco Caliandro, Benedetta Carrozzini, Yeonjeong Roh, Jihyeon Kim, Sunghwan Kim, 

      Sung Chul Ha, Masayo Morishita and Eric di Luccio

      Structure (Cell Press) (2019) https://doi.org/10.1016/j.str.2019.01.011  

28 - Identification of LEM-14 inhibitor of the oncoprotein NSD2

      Yunpeng Shen, Masayo Morishita, Doohyun Lee, Shinae Kim, Taeho Lee, Damiaan E.H.F. Mevius, Yeonjeong Roh, Eric di Luccio

       Biochem. Biophys. Res. Commun. (BBRC) (2019) doi.org/10.1016/j.bbrc.2018.11.037  

27- BIX-01294 inhibits oncoproteins NSD1, NSD2 and NSD3 

      Masayo Morishita, Damiaan E. H. F. Mevius, Yunpeng Shen, Shuyu Zhao, Eric di Luccio

      Med Chem Res (2017). doi:10.1007/s00044-017-1909-7 

26- Cloning, expression, purification and crystallization of Schizosaccharomyces pombe Set7, a putative histone 

      methyltransferase

      Damiaan E. H. F. Mevius, Yunpeng Shen, Masayo Morishita and Eric di Luccio 

      Acta Crystallographica Section F (2016) - F72, 263-268 

25-  Structure of the thermophilic l-Arabinose isomerase from Geobacillus kaustophilus reveals metal-mediated intersubunit

       interactions for activity and thermostability.

       Choi JM, Lee YJ, Cao TP, Shin SM, Park MK, Lee HS, di Luccio E, Kim SB, Lee SJ, Lee SJ, Lee SH, Lee DW.

       Arch Biochem Biophys. (2016) Mar 4;596:51-62. 

24 - WO PCT Patent: PCT/KR2014/002796 - (WO2015152437) NOVEL HISTONE METHYL TRANSFERASE INHIBITOR AND USE 

       THEREOF .

       Inventors: DI LUCCIO, Eric; MORISHITA, Masayo; LEE, Tae Ho - Published 08.10.2015 

23- The Structural Basis of Substrate Promiscuity in UDP-Hexose 4-Epimerase from the Hyperthermophilic 

      Eubacterium Thermotoga maritima.

      Shin SM, Choi JM, di Luccio E, Lee YJ, Lee SJ, Lee SJ, Lee SH, Lee DW.

      Arch Biochem Biophys. (2015) Nov 1;585:39-51  

22- Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06.

      Implication for Epigenetic Cancer Therapies.

      di Luccio E

      J. Cancer Prev. (2015) Jun;20(2):113-20 

21- In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L

      Morishita M, Damiaan Mevius, di Luccio E

       BMC Struct Biol. (2014) Dec 12;14(1):25 

20- Crystallographic observation of pH-induced conformational changes in the Amyelois transitella

      pheromone-binding protein AtraPBP1

      Eric di Luccio, Yuko Ishida, Walter S. Leal and David K. Wilson

      PLoS ONE (2013) 8(2) 53840 

19- The H-factor as a novel quality metric for homology modeling 

      di Luccio E & Koehl P

      Journal of Clinical Bioinformatics. (2012), Nov 2;2(1):18.  

18- Structural insights into the regulation and the recognition of epigenetic marks by the SET domain of NSD1

       Morishita M & di Luccio E

       Biochem. Biophys. Res. Commun. (BBRC) (2011) Aug 26;412(2):214-9.   

17- The NSD Family of Histone Lysine Methyltransferases and Cancers

       Morishita M & di Luccio E

       Biochim. Biophys. Acta (BBA) - Reviews on Cancer (2011) Jun 6;1816(2):158-163.    

16- Nrf2-mediated Induction of Phase 2 Detoxifying Enzymes by Glyceollins Derived from Soybean Exposed

      to Aspergillus sojae

       Hyo Jung Kim, Eric di Luccio, Ah-Ng Tony Kong and Jong-Sang Kim

       Biotechnology Journal  (2011) May;6(5):525-36      

15- A Quality Metric for Homology Modeling: the H-factor.

       di Luccio E & Koehl P

       BMC Bioinformatics (2011) Feb 4;12:48     

14- Effect of Cu2+ on the oxidative folding of synthetic maurotoxin in vitro

       Regaya I, Andreotti N, Di Luccio E, De Waard M, Sabatier JM

       J Biomol Struct Dyn. (2008) Aug;26(1):75-82    

13- Comprehensive X-ray structural studies of the quinolinate phosphoribosyl transferase (BNA6) 

      from Saccharomyces cerevisiae.

       di Luccio E, Wilson DK

       Biochemistry (2008) Apr 1;47(13):4039-50    

12- Structural and kinetic studies of induced fit in xylulose kinase from Escherichia coli.

       Di Luccio E, Petschacher B, Voegtli J, Chou HT, Stahlberg H, Nidetzky B, Wilson DK.  

       J Mol Biol. (2007) Jan 19;365(3):783-98    

11- Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies

       Di Luccio E, Elling RA, Wilson DK. 

       Biochem J. (2006) Nov 15;400(1):105-14   

10- Molecular modeling and docking simulations of scorpion toxins and related analogs on human SKCa2

      and SKCa3 channels. 

       Andreotti N, di Luccio E, Sampieri F, De Waard M, Sabatier JM. 

       Peptides. (2005) Jul;26(7):1095-108    

9- A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology

    and docking on K+ channels

     M'Barek S, Lopez-Gonzalez I, Andreotti N, di Luccio E, Visan V, Grissmer S, Judge S, El Ayeb M,  Darbon H,

     Rochat H, Sampieri F, Béraud E, Fajloun Z, De Waard M, Sabatier JM.

     J Biol Chem. (2003) Aug 15;278(33):31095-104

8- Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding

    and oxidation in vitro.

     di Luccio E, Matavel A, Opi S, Regaya I, Sandoz G, M'barek S, Carlier E, Estève E, Carrega L,  Fajloun Z, 

     Rochat H, Loret E, de Waard M, Sabatier JM.

     Biochem J. (2002) Jan 15;361(Pt 2):409-16   

7- A recombinant scFv/streptavidin-binding peptide fusion protein for the quantitative determination of the scorpion

    venom neurotoxin AahI

      Aubrey N, Devaux C, di Luccio E, Goyffon M, Rochat H, Billiald P.  

      Biol Chem. (2001) Nov;382(11):1621-8

6- Parameters affecting in vitro oxidation/folding of maurotoxin, a four-disulphide-bridged scorpion toxin.

     di Luccio E, Azulay DO, Regaya I, Fajloun Z, Sandoz G, Mansuelle P, Kharrat R, Fathallah M, 

     Carrega L, Estève E, Rochat H, De Waard M, Sabatier JM.

     Biochem J. (2001) Sep 15;358(Pt 3):681-92.   

5- Disulfide bridge reorganization induced by proline mutations in maurotoxin.

     Carlier E, Fajloun Z, Mansuelle P, Fathallah M, Mosbah A, Oughideni R, Sandoz G, Di Luccio E,  Geib S,     

     Regaya I,  Brocard J, Rochat H, Darbon H, Devaux C, Sabatier JM, de Waard M. 

     FEBS Lett. (2001) Feb 2;489(2-3):202-7

4- Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct

   disulfide bridge patterns

     Fajloun Z, Mosbah A, Carlier E, Mansuelle P, Sandoz G, Fathallah M, di Luccio E, Devaux C, Rochat H, 

     Darbon H, De Waard M, Sabatier JM.

     J Biol Chem. (2000) Dec 15;275(50):39394-402.

3- Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels

     Fajloun Z, Carlier E, Lecomte C, Geib S, Di Luccio E, Bichet D, Mabrouk K, Rochat H, De Waard M,  Sabatier 

     Eur J Biochem. (2000) Aug;267(16):5149-55.

2- Synthesis,1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore

    the consensus motif of scorpion toxins.

     Fajloun Z, Ferrat G, Carlier E, Fathallah M, Lecomte C, Sandoz G, di Luccio E, Mabrouk K, Legros C, 

     Darbon H, Rochat H, Sabatier JM, De Waard M.

     J Biol Chem. (2000) May 5;275(18):13605-12

1- Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release

    channel/ryanodine receptors.

     Fajloun Z, Kharrat R, Chen L, Lecomte C, Di Luccio E, Bichet D, El Ayeb M, Rochat H, Allen PD,  Pessah IN, 

     De Waard M, Sabatier JM.  

     FEBS Lett. (2000) Mar 10;469(2-3):179-85

© Eric di luccio - Kyungpook National University